| 22/08/2021 | 15:00 | RAS Pays Blanc Antoine B - Squadra Mouscron
| 3-5 |
| 29/08/2022 | 15:00 | Squadra Mouscron - Ent. Velaines Enclusienne A
| 5-2 |
| 05/09/2021 | 15:00 | DR Rongy A - Squadra Mouscron
| 4-3 |
| 12/09/2021 | 15:00 | Squadra Mouscron -FC Bleharies A
| 2-2 |
| 19/09/2021 | 17:00 | SC de Néchin - Squadra Mouscron
| 0-1 |
| 26/09/2021 | 15:00 | Squadra Mouscron - RFC Ellezellois A
| 5-1 |
| 03/10/2021 | 15:00 | RFC Tournai B - Squadra Mouscron
| 0-4 |
| 10/10/2021 | 15:00 | Squadra Mouscron - Renouveau US Tournai-Warcoing B
| 5-0 |
| 17/10/2021 | 15:00 | FC Beclers A - Squadra Mouscron
| 3-0 |
| 24/10/2021 | 15:00 | Squadra Mouscron - JS Wez-Guignies A
| 2-1 |
| 07/11/2021 | 14:30 | CS Taintignies A - Squadra Mouscron
| 0-5 |
| 14/11/2021 | 14:30 | Squadra Mouscron - FC Etoiles d'Ere B
| 4-0 |
| 21/11/2021 | 14:30 | Squadra Mouscron - RCS Escanaffles A
| 2-2 |
| 28/11/2021 | 14:30 | RAS Pays Blanc Antoine BCUL. Montkainoise A
| 1-4 |
| 05/12/2021 | 14:30 | Squadra Mouscron - US Thumaide A
| 3-1 |
| 12/12/2021 | 14:30 | Squadra Mouscron - RAS Pays Blanc Antoine B
| 0-5 |
| 09/01/2022 | 14:30 | Ent. Velaines Enclusienne A - Squadra Mouscron
| - |
| 16/01/2022 | 14:30 | Squadra Mouscron - DR Rongy A
| - |
| 23/01/2022 | 15:00 | FC Bleharies A - Squadra Mouscron
| - |
| 30/01/2022 | 15:00 | Squadra Mouscron - SC de Néchin
| 2-0 |
| 13/02/2022 | 15:00 | Squadra Mouscron - Diables Rouges Rongy A
| 3-3 |
| 17/02/2022 | 15:00 | Entente Velaines Enclusienne A - Squadra Mouscron | 0-2 |
| 20/02/2022 | 15:00 | F.C. Bleharies A - Squadra Mouscron
| 3-2 |
| 27/02/2022 | 15:00 | RFC Ellezellois A - Squadra Mouscron
| 1-2 |
| 20/03/2022 | 15:00 | Squadra Mouscron - FC Beclers
| 4-2 |
| 27/03/2022 | 15:00 | Squadra Mouscron - CS Taintignies A
| - |
| 03/04/2022 | 15:00 | FC Etoiles d'Ere B - Squadra Mouscron
| - |
| 17/04/2022 | 15:00 | Renouveau US Tournai-Warcoing BRCS Escanaffles A
| - |
| 24/04/2022 | 15:00 | Squadra Mouscron - CUL. Montkainoise A
| - |
01/05/2022
| 15:00 | US Thumaide A - Squadra Mouscron
| - |
R.A.S pays Blanc Antoinien
Squadra Mouscron
SC de Nechin
FC Bleharies A
FC Beclers A
F.C Ellezellois A
Cul. Monkainoise A
DR Rongy A
RFC Tournai B
US Thumaide
RCS Escanaffles A 
Entente Velaines Enclusienne A
