| 03/09/2021 | 20:00 | Futsal Topsport Antwerpen - Squadra Mouscron
| |
| 10/09/2021 | 20:00 | Squadra Mouscron - Futsal Team Charleroi
| |
| 17/09/2021 | 20:00 | K.K. Malle-Beerse - Squadra Mouscron
| - |
| 01/10/2021 | 20:00 | Squadra Mouscron - ZVC Renolim Borgloon
| - |
| 08/10/2021 | 20:00 | F.P. Halle Gooik - Squadra Mouscron
| - |
| 15/10/2021 | 20:00 | Squadra Mouscron - CB Futsal Jette BXL
| - |
| 22/10/2021 | 20:00 | Squadra Mouscron - Full Hasselt
| - |
05/11/2021
| 20:00 | Futsal My-Cars Châtelet - Squadra Mouscron
| - |
| 12/11/2021 | 20:00 | Squadra Mouscron - Proost Lierse
| - |
| 19/11/2021 | 20:00 | ZVK Eisden-Dorp - Squadra Mouscron
| - |
| 26/11/2021 | 20:00 | Squadra Mouscron - Real Noorderwijk
| - |
| 14/01/2022 | 20:00 | Squadra Mouscron - Futsal Topsport Antwerpen
| |
| 21/01/2022 | 20:00 | Futsal Team Charleroi - Squadra Mouscron
| |
| 28/01/2022 | 20:00 | Squadra Mouscron - K.K. Malle-Beerse
| |
| 04/02/2022 | 20:00 | FULL Hasselt - Squadra Mouscron
| |
| 11/02/2022 | 20:00 | ZVC Renolim Borgloon - Squadra Mouscron
| |
| 25/02/2022 | 20:00 | CB Futsal Jette Bxl Cap - Squadra Mouscron
| |
| 04/03/2022 | 20:00 | Squadra Mouscron - Futsal My-Cars Châtelet
| |
| 11/03/2022 | 20:00 | Proost Lierse - Squadra Mouscron
| |
| 18/03/22 | 20:00 | Squadra Mouscron - ZVK Eisden-Dorp A
| |
| 25/04/2022 | 20:00 | Real Noordewijk - Squadra Mouscron
| |
15/04/2022
| 20:00 | Squadra Mouscron - F.P. Halle-Gooik
| |
CB Futsal Jette Bxl Cap
F.P. Halle-Gooik
F.T Antwerpen
Full Hasselt
Futsal My Cars Châtelet
Futsal Team Charleroi
K.K. Malle-Beerse
Proost Lierse
Real Noorderwijk
Squadra Mouscron
ZVC Renolim Borgloon
ZVK Gelko Eisden-Dorp
